Low-dose oral methotrexate induces apoptosis of tissue eosinophils in bullous pemphigoid.

Methotrexate Induced Bullous Pemphigoid: a Case Report

Background: Bullous pemphigoid (BP) is an autoimmune cutaneous blistering disorder. The precise precipitating etiology is not clear. There has been documented Drug-induced BP in case reports. Case report: We describe a case of a 44year old female with a past medical history of Psoriasis, who developed bullous pemphigoid. She had previously been on maintenance dose of 10mg intravenous methotrexa...

Combined acute interstitial pneumonitis and pancytopenia induced by low-dose methotrexate in a hemodialysis patient treated for bullous pemphigoid*

Methotrexate has been widely used for many years in the treatment of a variety of diseases. Acute pneumonitis and bone marrow suppression are very serious side effects in methotrexate treatment. A 48-year-old man with end-stage renal disease undergoing chronic hemodialysis developed combined acute pneumonitis and pancytopenia after a cumulative dose of 20 mg methotrexate for bullous pemphigoid....

Remission of bullous pemphigoid after rituximab treatment in a psoriasis patient on regular low-dose methotrexate.

Increased Activity and Apoptosis of Eosinophils in Blister Fluids, Skin and Peripheral Blood of Patients with Bullous Pemphigoid.

Bullous pemphigoid (BP) is an autoimmune blistering skin disease that is more common in elderly individuals. The aim of this study was to determine the functional activity of eosinophils in patients with BP compared with healthy donors. Blood, skin and blister-derived eosinophils were strongly activated in patients with BP, seen by increased surface expression of CD69 compared with controls. CD...

Bullous Pemphigoid: A descriptive study on patients admitted in Loghman Hakim Hospital in Tehran in 1992-97

Background: Most of patients with bullous pemphigoid are at old age and its differentiation from other bullous diseases is important. There is no report of it in Iran. Objective: This study was done in order to determine clinical and paraclinical features, natural course and response to treatment in patients with bullous pemphigoid admitted in Loghman Hakim Hospital in 1992-1997. Patients and M...